Síndrome de las uñas amarillas. Presentación de un caso con estudio autópsico / Yellow nail syndrome. A case report with postmortem study

El síndrome de las uñas amarillas es una enfermedad rara de etiología desconocida, caracterizado por una coloración amarillenta de las uñas, manifestaciones respiratorias y linfedemas primarios1. Existe poca literatura científica en referencia a estudios autópsicos de pacientes con este síndrome, así como respecto a su etiología, si bien se postula que es causada por una malformación de los conductos linfáticos. En este artículo presentamos el caso de una paciente diagnosticada en vida de síndrome de las uñas amarillas en cuyo estudio autópsico se encontraron algunos hallazgos previamente no descritos, como dilatación de los senos de ganglios linfáticos mediastinales y esplénicos.(AU)

Yellow nail syndrome is a rare disease of unknown aetiology. Patients with YNS have a characteristic yellowish-coloured nails, pulmonary alterations and primary lymphedema. To the best of our knowledge, only a few reports of autopsy findings in these patients have been published. Its aetiology possibly involves a primary malformation of larger lymph vessels. We describe autopsy findings not previously associated with yellow nail syndrome, such as expansion of mediastinal lymph-nodes and splenic sinusoids.The present autopsy reveals hitherto unreported findings associated with YNS, such as alterations in splenic sinusoids and mediastinal lymph-node sinuses.(AU)

[Yellow nail syndrome. A case report with postmortem study]. / Síndrome de las uñas amarillas. Presentación de un caso con estudio autópsico.

Yellow nail syndrome is a rare disease of unknown aetiology. Patients with YNS have a characteristic yellowish-coloured nails, pulmonary alterations and primary lymphedema. To the best of our knowledge, only a few reports of autopsy findings in these patients have been published. Its aetiology possibly involves a primary malformation of larger lymph vessels. We describe autopsy findings not previously associated with yellow nail syndrome, such as expansion of mediastinal lymph-nodes and splenic sinusoids. The present autopsy reveals hitherto unreported findings associated with YNS, such as alterations in splenic sinusoids and mediastinal lymph-node sinuses.